Conference 3 Higher order genome architecture
(Scotland, April 1st - 5th, 2009)
Directions, Programme, All you need!
Registration and abstract submission closed February 6th, 2009
Nick Gilbert hosts the last MC-GARD meeting in Edinburgh. This 5th event will concentrate on the nuclear organisation and the role nuclear processes play in gene transcription, replication and repair. It is envisioned that in several years time the relationship between the tertiary structural organization of the DNA and chromatin in the nucleus and disease will become more evident. In this conference we will discuss why the nucleus is organised the way it is in relation to the genetics of heritable diseases and cancer. The meeting will furthermore focus on recent findings in the field of genome architecture and address how it might change for example during tumorigenesis, or in heritable diseases. Vice versa the influence of treatment regiments on the 3-D nuclear architecture will be discussed. New techniques are being developed to investigate nuclear processes including FRAP, FRET, ChIP-on-chip (chromatin immunoprecipitation arrays) and chromatin structure analysis and these new approaches should be expected to impact future prognosis and diagnostics. It will be discussed if and how these techniques for investigating higher order chromosomal organization can be adapted and introduced for prognostic and diagnostic settings and commercialised by various European companies.
Emphasis/Topics Human diseases related to chromatin biology, application to studying complex genetic disease, (3-D) image analysis and microscopy, ChiP-arrays DnaseI sensitive site mapping, Chromatin tertiary structure mapping e.g. 3-D, Human chromatin structure analysis
Confirmed speakers Wendy Bickmore (MRC Edinburgh, UK), Thomas Cremer (Uni. Munich, DE), Michael Speicher (University Graz, A).